The article is devoted to the development of an updated methodology of managing organizational innovation of industrial corporate structures. The hypothesis about the necessity to change the conceptual approach to the management of organizational innovation of industrial corporate structures in the digital economy is proved. A specific feature is that it is proposed to use a different approaches (conservative, adaptive, and proactive) in building an innovation and investment process (unimodal and multimodal), and the approach taken on its basis to investing in organizational innovation (entrepreneurial, advanced entrepreneurial, and responsible). The theoretical framework of the proposed methodology is the approaches and theoretical context to managing organizational innovations of industrial corporate structures, based on basic theories and research. The relevance of the article increases in connection with the modern context of the influence of digitalization and the concept of sustainable development (ESG) on the development of the industrial sector. The article describes the blocks of the conceptual approach to the proposed methodology, which consistently reveal the content of its elements. The article is theoretical in nature. However, with further disclosure and filling of the elements of the updated methodology, it can serve as a prototype of a digital solution for industrial corporate structures in the form of a database for the manager's monitor when making management decisions on the implementation of organizational innovations, which will increase the representativeness of data and simultaneously reduce risks.