The sanctions imposed by unfriendly countries against the Russian Federation since the beginning of the special military operation have affected all sectors of the economy to varying degrees. They had a particularly acute impact on the domestic industry, which is less flexible to external changes due to the complexity and availability of a large number of different processes. In the course of the study, the author analyzes the threats that the domestic industry faces with the introduction of sanctions restrictions. The prerequisites for the formation of such threats are identified. Modern economic and political reality has shown that the current model of economic development in the country requires serious changes. In the industry, the author proposes such a transformation through building new links based on an ecosystem approach under the prism of technological development, which will contribute to maintaining Russia's policy of import substitution. Acknowledgments: The article was prepared in accordance with the research plan of the Institute of Economics of the Ural Branch of the Russian Academy of Sciences on the topic No. 0327-2021-0009 Methodology of innovative development of regionally oriented systems in an unstable economic environment.